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Inhibition of lipid synthase activity: AOD 9604 reduces the activities of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), and decreases de novo synthesis of fatty acids

Regarding the metastization to the brain, Central Nervous System (CNS) has no lymphatic system, being the blood stream and the Blood-Brain Barrier (BBB) the pathway to melanoma reach the brain

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Setiawan 2017)

Synapse 75:e22221 Khan T, Waseem R, Zehra Z, Aiman A, Bhardwaj P, Ansari J et al (2022) Mitochondrial dysfunction: pathophysiology and mitochondria-targeted drug delivery approaches