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Semaglutide: product labeling advises discontinuation at least 2 months before a planned pregnancy, reflecting its long elimination time and extended exposure window (153, 157, 158)

Even after approval, compounding would only be permitted if retatrutide entered the FDA's drug shortage list, which happened with both semaglutide and tirzepatide

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In addition, patients with hyperthyroidism have increased rates of lipid peroxidation compared to euthyroid people, which is a sign of oxidative damage to membrane lipids (82)

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