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An honest caveat: there is no robust published human pharmacokinetic data for either compound

a , Systemic administration of IFNAR1 Ab (40 mg/kg, i.p.) one hour prior to cartilage autoantibody injection prevented mechanical allodynia (von Frey filaments) and administration on day 22 and day 45 reversed established allodynia and hyperalgesia compared to isotype IgG1 group (n = 6 per group)

Adverse effects such as nausea, vomiting, and gastrointestinal discomfort remain common, but usually diminish with time and proper dose escalation

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Additionally, the use of organoids and gene editing technologies is recommended to elucidate the mechanisms by which microbial metabolites, such as SCFAs, penetrate the bloodbrain barrier and their specific action targets on neurons

S4A) at the age of 48 months