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Such illness can lead to serious brain disorders like hepatic encephalopathy if treatment is not received

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Advances in mechanistic understanding have revealed a multifactorial pathogenesis, characterised by dysregulated inflammation, disruption of the gut-liver axis, oxidative stress, impaired regeneration, and genetic susceptibility, each of which offers rational targets for intervention

145 XieB.XingR.ChenP.GouY.LiS.XiaoJ.et al (2010)