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It exerts its effects through two primary pathways: direct binding to the GH receptor (GHR) on target tissues producing immediate metabolic effects including lipolysis, insulin antagonism, and protein synthesis and indirect stimulation of IGF-1 production in the liver and peripheral tissues, which mediates the majority of GHs anabolic and growth-promoting effects

6.3.4 Regulation of triacylglycerol and phospholipid synthesis GPT2 regulates the synthesis of PC and TAG, participating in CS-induced lipid metabolic reprogramming in airway epithelial cells

doi: 10.1016/j.jep.2017.03.005

/ Cancer Res

One way that insulin resistance affects hormones is by disrupting the function of the hypothalamic-pituitary-adrenal (HPA) axis, which is a complex system that regulates the bodys stress response.In insulin resistance, the body produces more cortisol, a stress hormone that can lead to a range of negative effects, including weight gain, increased appetite, and decreased insulin sensitivity

Redox imbalance in age-related ovarian dysfunction and perspectives for its prevention