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cholestasis is generally mild and intermittent, with pruritus, normal GT, elevated BAs, and transaminases, but liver fibrosis is often present [42, 50, 51]

Clear headline finding from human trials Systematic reviews and metaanalyses of randomized human trials through 2024 report a modest average effect: pooled data show mean body weight reductions around 1.1 kilograms and fatmass reductions near 1.15 kilograms compared with placebo

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