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Activation of FXR or TGR5 by SBAs is reported to inhibit transcription in the p65 subunit of the NF-B pathway as well as exert anti-inflammatory effects in the intestine[62]

1 Now, in 2023, we know his astute instinct was likely correct as we continue to learn how the gut microbiome and the numerous compounds it produces play a critical role in the prevention of many chronic diseases

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Conversely, someone with recent-onset diabetes and substantial weight loss may potentially reduce therapy if lifestyle changes are maintained and glycaemic control remains stable