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Administration of butyrate-producing bacteria (e.g., Faecalibacterium prausnitzii , Ruminococcus , Roseburia ) has been shown to upregulate GPX4 and SLC7A11 in intestinal epithelial cells (Lee et al., 2025)

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While in the absence of light, the inhibition is released, allowing for the synthesis of melatonin as the SCN activity drops, which allows the paraventricular nucleus to start activating the intermediolateral cell column, which in turn activates the superior cervical ganglion and finally postganglionic fibers that directly affect the pineal gland with the help of norepinephrine that binds to 1 -adrenergic receptors to start melatonin synthesis (178)

Keene DE, Suescun MO, Bostwick MG, et al