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Although the increased exposure to exogenous estrogen could enhance the development of adenomyosis, the use of low dose estradiol formulations can also be effective in decreasing endogenous production of this steroid, potentially reducing disease risk (Upson and Missmer, 2020)

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doi: 10.1073/pnas.0712245105 41 KchEMVellaramkalayilRZhangILehnenDBrggerBSreemmelWet al

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The amygdala is overactive in people with depression, which may correlate with heightened emotional responses and negative affective states [23,28]