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A controlled trial in 90 men with low sperm numbers and motility found 400 mg vitamin E daily enhanced the benefits of clomiphene citrate (Serophene, Clomid) on sperm parameters after six months

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For instance, using a human embryonic stem cell model, Lechner and colleagues showed that reduced POMC gene expression was associated with increased POMC methylation in POMC-expressing neurons and they identified an epigenetic obesity risk variant at the POMC gene, which carries a 1.4-fold increased risk of developing obesity in humans [82]

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