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A cross-sectional analysis published in Hormone Research in Paediatrics found that children and adolescents with untreated GHD scored significantly lower on the Pediatric Quality of Life Inventory compared with healthy controls, with particular deficits in psychosocial and school-functioning domains [14]

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A metabolite of acetaminophen also acts on the TRPV1 and TRPA1 receptors to decrease pain.[ref] While generally safe when taken as directed, higher doses of acetaminophen can lead to severe liver damage and potentially fatal liver failure

Meas et al., 2020