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non-tremor dominant responsiveness to L-DOPA PD is a disorder with various motor subtypes, but few neuroimaging studies have examined the variable effects of L-DOPA treatment on the different motor sub-classifications of Parkinsons

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When the annulus tears or weakens, the nucleus can bulge or herniate, potentially compressing spinal nerves

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Injecting it in the morning or mid-day works against the mechanism