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Hence, the degradation of GSH by CHAC1 not only induces NRF2 activation but also creates a feedback loop where NRF2 enhances the cells capability to cope with oxidative stress by regulating cystine uptake and antioxidant responses

Early studies provided evidence for GST activity in hepatic microsomal fractions (Booth et al

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This suggests that SLC7A11 not only plays a critical role in protein and GSH synthesis through cysteine uptake but also dictates glutamine dependence 61

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