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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Quek J., Chan K.E., Wong Z.Y., et al

Best practice recommendations include: Comprehensive assessment before initiating any weight-loss medication, including cardiovascular screening, mental health evaluation, and review of current medications Monotherapy first : Trying one evidence-based medication at an appropriate dose before considering alternatives Regular monitoring : Scheduled follow-up appointments to assess weight loss, side effects, blood pressure, heart rate, and overall wellbeing Diabetes monitoring : For patients with diabetes, regular review of HbA1c/glucose levels and adjustment of insulin or sulfonylureas as needed to prevent hypoglycaemia Lifestyle integration : Ensuring medication is used alongside dietary changes, physical activity, and behavioural support Individualised treatment plans : Tailoring approaches to patient-specific factors, comorbidities, and preferences If you are considering weight-loss medication or are currently taking Mounjaro or phentermine, schedule a thorough consultation with your GP or a specialist in obesity medicine

L-ornithine L-aspartate (LOLA) Ammonia detoxification is achieved by two main pathways in periportal hepatocytes: 1) urea synthesis in zone 1 and 2) glutamine synthesis in zone 3

The emergence of semaglutide has ushered in a new era of obesity treatment

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Honest framing of unknowns is part of responsible care