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And it produces the steady-state pharmacokinetics that allow once-weekly dosing

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In some cases, bloating and gas may indicate gastroparesis (paralysis of the stomach due to ineffective contractions)

If significant diarrhea occurs, fiber capsules or powders provide bulk to the stool, and anti-diarrheal medications can provide acute relief

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Diarrhea affects 15-23% of patients and may range from mild loose stools to frequent watery bowel movements