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25 In semaglutide, a fatty acid chain is attached at this site and the affinity and activity are boosted

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The 80% increase in dentate gyrus neurogenesis and the reversal of dendritic and synaptic density loss make P21 particularly suited to the recovery phase, where the goal is not preventing further damage but restoring function

Two structural modifications (C18 fatty acid chain enabling albumin binding, and a substitution at position 8 conferring DPP-4 resistance) extend its half-life to approximately 1 week, enabling once-weekly subcutaneous dosing

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