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Individuals with known allergies to cobalt or vitamin B12, or those with Leber's disease (hereditary optic atrophy)

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Your healthcare provider may consider your overall health, medical history, blood sugar levels, weight management goals, medication tolerance, and lifestyle habits before recommending a treatment option

10.1016/j.kint.2017.03.053 107 ToyoharaT.AkiyamaY.SuzukiT.TakeuchiY.MishimaE.TanemotoM.et al (2010)

In patients with type 2 diabetes mellitus (T2DM), supraphysiological doses of GLP1 normalize the endogenous insulin response during a hyperglycaemic clamp

The ER is a central organelle for proinsulin folding, a capacity that is often overwhelmed in insulin-resistant states (Sharma et al., 2011)