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Ipamorelin emerged from this programme as the first truly selective GHS-R1a agonist , a pentapeptide incorporating alpha-aminoisobutyric acid (Aib) at position 1, His at position 2, the unnatural D-2-naphthylalanine residue at position 3, D-Phe at position 4, and C-terminal Lys-NH2 and a structural solution that achieves high-affinity GHS-R1a binding and potent GH release while eliminating the receptor interactions responsible for prolactin and cortisol co-stimulation in non-selective first-generation GH secretagogues
doi: 10.1007/s00204-019-02467-w 149 FullerRLandriganPJBalakrishnanKBathanGBose-OReillySBrauerMet al
Levack, V
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Because the peptide was still shown to be effective 14 days post-injury, the researchers suggested that there is increased activity of wound healing mechanisms to increase mechanical strength, as well as an increase in potentiated activity that could lead to beneficial results
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