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Excess free metal ions, such as iron (Fe 2 ), can catalyze the formation of ROS through Fenton reactions, leading to oxidative stress and cellular damage (Kotha et al., 2022

[DOI] [PMC free article] [PubMed] [Google Scholar] 170.Rojas B., Gallego B.I., Ramrez A.I., Salazar J.J., de Hoz R., Valiente-Soriano F.J., Avils-Trigueros M., Villegas-Perez M.P., Vidal-Sanz M., Trivio A., et al

Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor

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Conversely, B12 deficiency may have an effect on metabolism that plays a role in obesity