Tirzepatide reduces muscle fat infiltration relative to insulin deglucec in people with type 2 diabetes (SURPASS-3 MRI)
43 Exenatide significantly decreased TNF-, MCP-1 and ROS secretion, which may be associated with the activation of adenylate-activated protease (AMPK) and inhibited the inflammatory process through interaction with NF-B, CCAAT/enhancer binding protein (C/EBP) and mitogen-activated protein kinase (MAPK) (p38, ERK and JNK)
Below, we review the current landscape of oral GLP-1 drugs, how they work, and how they compare to their injectable counterparts
NICE guidance (NG28) on type 2 diabetes management includes GLP-1 receptor agonists like Ozempic as treatment options, and efforts should be made to support patients through the initial side effect period when clinically appropriate
Theres always an element of that in there
it's about combining peptides that work on complementary pathways to address a clinical problem from multiple angles simultaneously, creating a result that is greater than the sum of its parts