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There is a pressing need for standardized diagnostics and longitudinal studies to clarify the temporal relationship between microbiome changes and disease onset, as well as to identify reliable microbial or metabolic biomarkers for early detection and targeted intervention (Dai et al., 2024

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3.1.5 Chronic rhinosinusitis without nasal polyps Chronic rhinosinusitis (CRS), defined by chronic inflammation of the paranasal sinuses, is a common comorbidity in individuals with chronic lower respiratory conditions, such as COPD, bronchiectasis, CF, and asthma (126129)