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For the tumour allograft model, Gclc f/f Rosa26 creERT2 MMTV-PYMT mice were euthanized and autochthonous tumours were collected, cut into 8 mm 3 fragments and cryopreserved in liquid nitrogen

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They represent the epineural and perineural vessels of the nerves, usually invaded and destroyed by inflammatory cells and/or immune complexes, leading to necrotizing vasculitis and lumen occlusion [61,62]

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HDTVI Hydrodynamic tail vein injection (HDTVI) was performed to deliver transposon-based vectors as previously described with minor modifications 53