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Compounds such as alpha-chloroacetamide-based inhibitors achieve this by covalently binding to a cysteine residue in the SAM-binding pocket of NNMT 202

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We integrate findings from experimental models with clinical observations that highlight the translational relevance of this interplay

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doi: 10.1016/j.prp.2024.155553 47 SangkhaeVNemethE

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This pathway has been shown to contribute to synaptic dysfunction, neuroinflammation and glutamate dysregulation 60

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References NIST Chemistry WebBook

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The main mechanisms with research support: Collagen and connective tissue: GHK-Cu upregulates collagen synthesis and metalloproteinases the enzymes that remodel old, damaged collagen

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