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Conclusion In conclusion, higher baseline 25(OH)D levels are associated with improved glycemic control and weight loss following semaglutide therapy in patients with T2DM

The review confirmed GLP-1R is expressed at high levels on -cells, where GLP-1 stimulates somatostatin secretion which in turn indirectly suppresses both glucagon and insulin through paracrine mechanisms

( 10.1016/j.rbmo.2015.02.006) [DOI] [PubMed] [Google Scholar] Omar MI, Pal RP, Kelly BD, Bruins HM, Yuan Y, Diemer T, Krausz C, Tournaye H, Kopa Z, Jungwirth Aet al

Signaling by gasotransmitters

Endocrinology 149:23412351 Lien F, Berthier A, Bouchaert E et al (2014) Metformin interferes with bile acid homeostasis through AMPKFXR crosstalk