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In this state, excess glucose is diverted into fatty acid synthesis via de novo lipogenesis, driven by the transcription factor sterol regulatory element binding protein-1c, which is upregulated under hyperglycemic conditions

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Liraglutide (Saxenda): An earlier GLP-1 approved for weight management, administered as a daily injection

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The subsequent development of other GIP/GLP-1 receptor co-agonists confirmed these initial discoveries and the superior action profile of this drug class in obese rodents [85,86,87]

Because of its stability, LH is most frequently a polyunsaturated fatty acid (PUFA)