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Dysregulation of the immune system impairs the function and number of Treg cells, which are essential for maintaining self-tolerance, while increasing the differentiation of proinflammatory Th1 and Th17 cells [34,35,36]

These results demonstrate that TGF--induced transition from fibroblasts to myofibroblasts involves canonical TGF-/Smad2/3 signaling, non-canonical TGF-/ERK1/2 signaling, and ROS production via NAD(P)H oxidase

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Dispose of the Needle: Remove the needle from the skin and dispose of it in a sharps container

doi: 10.1016/S0092-8674(00)80721-7 42