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The role of cystine/glutamate antiporter SLC7A11/xCT in the pathophysiology of cancer

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Specifically, dietary supplementation of L-arginine increases the percentage of CD8 + cytotoxic T lymphocytes in cancer, enhances immunogenic tumor immunity, and strengthens innate and adaptive immune responses, thus prolonging the patients survival time [246]

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The compound's selectivity profile minimizes concerns about off-target effects, but investigators should consider potential interactions with other NAD+-modulating interventions or compounds that affect methylation metabolism