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Pain 138:318329 Al-Khrasani M, Lack E, Riba P, Kirly K, Sobor M, Timr J, Mousa S, Schfer M et al (2012) The central versus peripheral antinociceptive effects of -opioid receptor agonists in the new model of rat visceral pain

Supplementation of dietary glutamate to healthy weaning piglets led to an increase in overall intestinal health, as evidenced by higher villus height and enhanced intestinal mucosal thickness and integrity (122, 134)

"Tolerating well" means minimal or no nausea, no vomiting, and no significant gastrointestinal distress

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Meanwhile, other ingredients (NALT, Velvet Bean) support dopamine production, which sustains focus & energy for up to 3x longer vs coffee, with no crash, tolerance or dependency