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5.1 Storage EXOs are a potential cell-free treatment

What to do (patient + clinician-friendly): Do not stop meds without guidance

For example, a study of 643,687 levothyroxine users found that over-replacement was associated with higher AF risk (OR: 1.31, 95% CI: 1.241.38), while another study showed increased stroke risk (OR: 1.33, 95% CI: 1.241.43) [19, 36]

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Inhibiting NNMT has been proposed as a therapeutic strategy for metabolic disease

For the extraction of mRNA, tissue samples were homogenized in TRI Reagent (Molecular Research Center) using a TissueLyser II system (Qiagen) and then chloroform extracted, precipitated using isopropanol, washed with 75% ethanol, and reconstituted with DEPC-treated water