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This process is driven by the failure of cellular antioxidant defenses, particularly the GPX4 system, which neutralizes typically lipid peroxides using glutathione (GSH) [86, 87]

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Strong clinical documentation is critical and should include: Mechanism of injury (e.g., whiplash, fall) Physical exam findings (tenderness, spasm, ROM limitation) Symptom correlation and treatment plan Clear linkage between diagnosis and management supports medical necessity and audit compliance

The plasma or plasma components can then be used for different medical treatments

It has been proposed that depletion of hepatic GSH, particularly mitochondrial GSH, is one of the early changes associated with chronic alcohol consumption and is a critical contributor to ALD pathogenesis 11

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