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Unlike standard IGF1, the LR3 version has two key modifications that enhance its potency and duration: The Long designation refers to an additional 13 amino acids, increasing its molecular stability The Arg3 substitution reduces its binding to IGF-binding proteins (IGFBPs), extending half-life from minutes to ~2030 hours These changes allow IGF1 LR3 to remain active in the bloodstream much longer than endogenous IGF1, resulting in greater anabolic signaling and sustained muscle growth potential
However, current evidence is primarily from lab and animal studies, which may not directly apply to humans
As an oral medication, it might be more appealing to those wary of injections
doi: 10.1177/1178646920936279 46 LongoNFrigeniMPasqualiM
GHK-Cu (Copper Peptide) GHK-Cu is a naturally occurring copper-binding peptide found in human plasma, studied for its role in collagen synthesis, wound healing, skin repair, and hair follicle support
The most frequent adverse events associated with resmetirom were diarrhea and nausea
