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10.1371/journal.pmed.1002773 184 SullivanO.PoitevinF.SierraR

For ultra-orphan drugs at prices of $300,000 to $500,000 per patient year, seven years of exclusivity on a 3,000-patient market can generate more than $1 billion in cumulative revenue

Dose escalation can temporarily restart or worsen diarrhea, especially if you increase your dose quickly

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Medical College, Ambajogai