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That does not prove every use is ineffective or every dose is unsafe

Within the TME's boundaries, Treg cells exert control over T cells, NK cells, MDSCs, and macrophages through humoral and intercellular interactions, while also producing molecules like cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), IL-2, IL-10, and TGF-, contributing to the management of immunosuppression [88]

These molecules cause "oxidative stress," which is essentially biological rust

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However, high doses may not provide extra benefits and should be avoided