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On average, people lose about 5 percent of their total body weight on phentermine, compared to 15 percent on Wegovy (8, 10)
Food-effect bioavailability and fed bioequivalence studies
Microdosing protocols, by contrast, operate in a completely different range
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In the landmark SURPASS-2 trial published in the New England Journal of Medicine, tirzepatide at its highest dose (15 mg) achieved roughly double the weight reduction of semaglutide 1 mg at 40 weeks
People taking Wegovy lost an average of about 15% of their body weight over 68 weeks
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