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As obesity, oncology and cell and gene therapy programs move beyond their original boundaries, success will hinge on more than ambition

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The GLP-1 receptor (GLP-1R) is an established drug target for the treatment of diabetes and obesity 2 , whereas the therapeutic potential of the GIP receptor (GIPR) is a subject of debate

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Clonidine is another kind of 2 adrenergic agonist that acts on the nerve terminals of primary afferent fibers, it can inhibit the release of norepinephrine, GLU, substance P, and pro-inflammatory cytokines, thereby reducing peripheral inflammation (Lavandhomme and Eisenach, 2003)