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There is no scientific evidence that B12 shots directly promote weight loss in people without deficiency

however, their efficacy is influenced by colonization rates

Niacin or B3 Taking high-dose niacin supplements can result in skin-related allergic reactions, such as extreme facial flushing, also referred to as niacin flush. Flushing causes generalized itching and a burning sensation that is typically limited to the face and chest and lasts 20 to 30 minutes(1)

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B12 injections offer a direct route for this essential nutrient, bypassing potential absorption issues in the gut