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After allowing tumours to develop in these mice, the tumours were excised and orthotopically implanted into recipient immunocompetent wild-type (WT) mice (C57BL/6)

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Moreover, intra-articular injection of monoiodoacetate (MIA) induces loss of articular cartilage with subchondral bone lesions that mimic those of human OA and This model offers a rapid and minimally invasive method to reproduce OA-like lesions in a rodent species [13]