Everything below describes research and clinical findings only
Tumor cells take up a large amount of glutamine to meet their rapid proliferation requirements, which is supported by the upregulation of glutamine transporters
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Grandt AD, Schimiczek M, Beglinger C, Layer P, Goebell H, Eysselein VE, et al
On the other hand, other biguanides (not limiting to anti-diabetic compounds) were tested for their potential anti-cancer properties in different types of cancer
however, this combination has generated contrasting outcomes with excessive DNA damage, which is likely associated to pro-oxidant effects [125]