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Most secondary endpoints were not measured at screening, therefore several biochemical changes brought about by weight loss during run-in cannot be evaluated

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Potential Market Implications: For Patients: May see increased access and improved affordability

Losartan is often prescribed for serious cardiovascular or renal conditions, and stopping it without supervision may lead to a rise in blood pressure and worsened cardiovascular control

The struggle feels deeply unfair because eating and exercise habits often have not changed, yet the body responds completely differently

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