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However, electrophysiological studies revealed that GLP-1 or exendin-4 does not change the spontaneous firing activity as well as the synaptic transmission suggesting lack of functional GLP-1R in PPG neurons (Reiner et al., 2016)

Touny AA, Kenny E, Mnsson M, Webb DL, Hellstrm PM

Additional factors to consider: Existing hypertension Existing lipid dysfunction (elevated LDL/Triglycerides) Semaglutide for weight loss purposes has recently received FDA authorization for chronic weight management

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(PubMed) Azen SP, Qian D, Mack WJ, et al

2) Brain In the brain, GLP-1 is produced by noncatecholaminergic neurons of the nucleus of solitary tract (NTS)43)