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This systemic condition arises predominantly due to the interplay of two key components: (a) compromised insulin production by the pancreatic -cells, and (b) the failure of insulin-sensitive tissues to react to insulin

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In some embodiments, the amount of thermoreversible polymer (e.g., pluronic F127) in any formulation described herein is about 14% of the total weight of the formulation

In the vasculature, cuproptosis directly induces EC death and drives VSMCs toward a pro-inflammatory synthetic phenotype

Together, they constitute a critical cooperative antioxidant barrier for cellular protection