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Methodical advances in reproducibility research: A proof of concept qualitative comparative analysis of reproducing animal data in humans

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This means a lower and less predictable amount of the active compound might reach systemic circulation, potentially requiring higher doses and introducing variability into research findings

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Several studies indicated that topical anti-glaucoma therapy with prostaglandin analogs induced a significant decrease in central corneal thickness, as well as in patients with normal tension glaucoma [86,87,88,89]