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19 One study evaluating MACI with long-term follow-up (512 years) found failure rates of 18.2 and 87.5% in complex and salvage cases, respectively, compared to a failure rate of only 4.3% in less complex cases

They function by neutralizing free radicals

In addition to the primary performance and health "markers" measured by the researchers, secondary markers also increased in the combo group: O2 pulse, total haemoglobin and myoglobin in skeletal muscle tissue, and BAP (a test designed to assess the Biological Antioxidant Potential of blood plasma)

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Science 349 , 11151120 (2015)

The initiation of cuproptosis critically depends on mitochondrial oxidative stress, as the oxidation of lipoyl groups on target proteins is a prerequisite for their high-affinity binding to Cu, which drives toxic protein aggregation [3]