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Participants also experienced improvements in trunk fat, waist circumference and waist-to-hip ratio, along with increased IGF-1 levels, indicating enhanced growth hormone activity

Since isolated primary human islets cannot be cultured for extensive periods of time and exhibit donor-to-donor variability, most groups have historically relied on rodent models and cell lines to robustly understand the genetic and mechanistic components involved in the initiation and progression of T1D

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