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In research settings, it is valued for its broad systemic activity and its ability to influence healing pathways across multiple tissue types

Individuals at higher risk of experiencing adverse effects are those who use semaglutide drugs in high doses, for extended periods, or specifically for weight loss purposes

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However, the orthopaedic community has been reluctant to recommend surgical intervention except for the most severe cases because the outcomes of this surgery are not as predictable as we would like