To see how this science plays out in practice, lets compare the USs current gold standard, Zepbound, to one of the most anticipated pipeline drugs, Retatrutide
The latter is subdivided into apoptotic and non-apoptotic cell death
In addition to the cell culture media described above, strial explants can also be maintained in the following media: MEM with Earle's salts, 15 mM HEPES buffer, 2 mM L-glutamine, 10 mg/L MEM non-essential amino acids, 2.5 mg/L fungizone, 100 units/ml penicillin, 100 mg/L streptomycin, 400 g/L hydrocortisone, 5 mg/L transferrin, 2 nM triiodothyronine, 5 mg/L insulin, 100 M cholera toxin, 10 g/L epidermal growth factor, and 10% fetal calf serum
You also want to choose a spot that is not reddened or hard
It belongs to a class of medications called GLP-1 receptor agonists, originally developed to treat type 2 diabetes
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