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doi:10.1677/joe.0.1730465 285

En tant qu'agoniste de trois rcepteurs hormonaux, son mode d'action molculaire unique fait l'objet de recherches internationales approfondies

Mitochondrial dysfunction in HD includes impaired electron transport chain activity, reduced mitochondrial biogenesis, and defective mitophagy, all of which contribute to increased oxidative stress and neuronal damage [165]

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Gastrointestinal side effects including nausea, vomiting, diarrhea, and constipation remain the most common adverse effects and occur more frequently at the 7.2 mg dose (approximately 71%) than at 2.4 mg (approximately 61%)