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One could therefore argue that outcome-relevant GPx3 optimization could not be achieved due to the dosing regimen of the SUSTAIN CSX trial: the first selenium dose was administered shortly prior to CPB and the inflammatory insult, leaving little time for selenoprotein biosynthesis and tissue protection
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10.1056/NEJMoa2200644 N Engl J Med
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Although most studies have focused on bacterial changes such as increased Streptococcus and Veillonella and decreased Faecalibacterium 63,64,65,66 , fungal involvement is supported by clinical observations of severe fungal infections in PSC patients 67,68 and serological evidence such as elevated ASCA in PSC populations 69