One theory is the increased DVT risk may be tied to diarrhea and dehydration common with semaglutide use
Exendin-4(1-32)K-capric acid (Ex-4c) directly activates pro-opiomelanocortin (POMC) neurons via the stimulation of glucagon-like peptide-1 receptors (GLP-1Rs)
Chan JCN, Lim LL, Wareham NJ, Shaw JE, Orchard TJ, Zhang P, Lau ESH, Eliasson B, Kong APS, Ezzati M, Aguilar-Salinas CA, McGill M, Levitt NS, Ning G, So WY, Adams J, Bracco P, Forouhi NG, Gregory GA, Guo J, Hua X, Klatman EL, Magliano DJ, Ng BP, Ogilvie D, Panter J, Pavkov M, Shao H, Unwin N, White M, Wou C, Ma RCW, Schmidt MI, Ramachandran A, Seino Y, Bennett PH, Oldenburg B, Gagliardino JJ, Luk AOY, Clarke PM, Ogle GD, Davies MJ, Holman RR, Gregg EW
S.AfraJ.AmbrosiniA.SchoenenJ
2 Given that achieving a healthy weight can prevent the progression from prediabetes to T2D and result in T2D remission with just a 10-15% total body weight loss, it is unsurprising that use of GLP1 RAs has surged, with 12% of all U.S
More common with intramuscular administration than subcutaneous
