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& Nunemaker, C

BEHIND THE HYPE-- GLP-1 MEDS: We spent months digging into the benefits and costs involving GLP-1 medications

Lupus involves autoantibody production, complement activation, and immune complex deposition, pathways that are not directly targeted by GLP-1 or GIP receptor activation

It acts as a substrate linker for the interaction of Cullin 3 (CUL3)-dependent E3 ubiquitin ligase complex [119], with NRF2 leading to continuous ubiquitination and proteasomal degradation of NRF2 [120], thus representing the main negative regulator of NRF2 activity

Values above 0.5 or 1 were considered indicative of an increased risk of liver fibrosis or cirrhosis, respectively ( The Hepatic Steatosis Index (HSI), used to estimate the risk of liver steatosis, was calculated according to the following formula: [8 (AST/ALT) + BMI + 2 + 2 if female]

Singh RB, et al